Development organizations have used value chain analysis in defining interventions for the honey business in major exporting countries like Brazil. Yet, the impact of interventions has been unclear. This paper aims at evaluating strategies of three honey value chain streams in Brazil, selected for a multiple case study between the years 2007–2011.Using the value chain Structure-Conduct-Performance (SCP) framework, likely successful strategies are identified by comparing stream performances. Next, the outcomes of this comparison are validated through questionnaires with experts. Understanding current stream strategies and local structural conditions, and fostering well-aligned strategies are found to be key for successful donor interventions.